• Dodt gradient contrast microscopy | Published in BioPhotonics

    by Michael O'Coyne | Dec 07, 2017
    48220000Imaging transparent, colorless specimens has always presented a challenge in optical microscopy. In many applications, it is not desirable or even possible to use fluorescent dyes, stains or transgenic probes to render target objects more visible.  While differential image contrast (DIC), often in the form of the Nomarski microscope, is widely employed, its optical complexity can cause limitations when the contrast image is combined with some other measurement modality or imaging technique (such as patch-clamp measurements or optogenetic stimulation, or even simply epi-fluorescence)..... Biophotonics 2017-11 Microscopy

  • Neuroscience Under the Microscope | Published Article from Novus Light

    by Michael O'Coyne | Aug 15, 2017

    NovusLight-figure-1While optical microscopy methods for neuroscience have expanded significantly in recent times, traditional tools such as patch clamp technology are still widely used because they provide superior data for many types of experiments. Researchers at the AstraZeneca-Tufts Laboratory for Basic and Translational Research are using patch clamp technology to study fundamental aspects of synaptic inhibition that are associated with epileptic-type seizures. This Institute itself is an exciting new business model in the world of neuroscience research, created as a joint collaborative venture between a leading academic institution and a highly respected pharmaceutical giant. (read more .....)

  • Siskiyou Appoints eQuestus as U.S. Western Regional Representative

    by Michael O'Coyne | Feb 27, 2017
    Siskiyou Corporation has appointed eQuestus Corp. as their exclusive sales representative for the western United States (AZ, CO, ID, MT, NV, NM, OR, UT, WA, WY, CA, NV and UT).  (read more....)
  • Modular Accessories Expand, Published in BioPhotonics

    by Michael O'Coyne | Feb 27, 2017
    Modular Accessories Expand; Fluorescence Microscope Capabilities.
    From neuroscience to morphogenesis and photosynthesis, optomechanical modules allow researchers to utilize fluorescence microscopy in diverse and increasingly complex studies.
    (read more ....)



  • Press Release, as seen at electrooptics.com

    by Michael O'Coyne | Oct 06, 2016
    Components for customising microscopes.  Siskiyou now offers a set of interchangeable modules and accessories for customising the
    functionality of optical microscopes from all major manufacturers (Zeiss, Nikon, Olympus), or even for building a new microscope. (read more...)


  • Ultra-stable micromanipulators, as seen in Laser Focus World

    by Michael O'Coyne | Oct 04, 2016
    Among the DC/servo options, the MX7000 series demonstrated the lowest amount of play and drift compatible with MyoStretcher’s target performance (measurement to 1 nN), while providing up to 20 mm of motion in each axis. A motorized actuator with anti-backlash gear-head (in each axis), driving a crossed roller-bearing highly linear stage, eliminates axial and lateral play, and a pre-loaded screw drive avoids the possibility of drift when stationary—that is, during a typical single myocyte experiment. Also, because the three-axis subsystems were originally developed for demanding electrophysiology (patch clamp) experiments, they are totally compatible with the limited access of a high-magnification optical microscope.  (read more...)

  • OEM Integration of the IXF1.0i, Published in Laser Focus World

    by Michael O'Coyne | Jun 15, 2016
    High-stability flexure mounts were crucial to Opotek’s miniaturized, shippable OPO with its shipping-based technical support model (a). Thermal stability (averaged over both x and y-axes) is shown for a Siskiyou IXF1.0i monolithic flexure mount and high-stability kinematic mounts from two other manufacturers (b). Thermal performance data for the latter two are from manufacturers’ published literature. (read more...)

  • Press Release, as seen on Photonics.com

    by Michael O'Coyne | May 02, 2016
    GRANTS PASS, Ore., April 25, 2016 — The 50.5cr crossed roller stages from Siskiyou Corp. are designed for space- or weight-constrained applications. The stages feature a non influencing foil lock mechanism, and offer a linear travel range of 12 mm and 33 × 33-mm mounting platform. 
    The stages are compatible with both manual and motorized actuators from Siskiyou, including 80 TPI and 100 TPI pitch screws, an ultrahigh resolution differential micrometer, and the company’s 512 series motorized actuators.  Applications include microscopy, intracavity adjustments in laser, and medical device incorporation. (read more ....)


  • Published Article from Novus Light

    by Michael O'Coyne | Mar 08, 2016
    After decades of promise and hype, but very limited market uptake, laser systems for dentistry are finally taking off.  One of the leading products is the Solea from Convergent Dental, which provides a superior alternative to the mechanical drill, plus the flexibility of several soft tissue procedures, including wound sealing, and even cutting/ osseous tissue (bone).  This article reviews the development of this system, including the use of novel optomechanics from Siskiyou Corporation to simplify system assembly, improve stability and reduce cost. (read more ....)

  • Published Article from BioPhotonics

    by Michael O'Coyne | Oct 14, 2015

    Comparing Micromanipulators ​for Electrophysiology

    Several different technologies offer a range of performance options within the confines of an optical microscope for patch-clamp studies, intracellular recording and other demanding experiments in electrophysiology. (read more ....)

  • Published Article from BioOptics

    by Michael O'Coyne | Oct 14, 2015

    Boosting conventional microscopes for optogenetics

    A simple, modular optomechanical tool breaks barriers by enabling the seamless addition and control of a secondary light source in standard microscopy setups. The cost-efficient tool facilitates not only photoactivation for optogenetics, but also extends microscope imaging capabilities. (read more ....)

  • Press Release, Dual-Wavelength Excitation Light Source

    by Michael O'Coyne | Sep 15, 2015
    GRANTS PASS, Ore., Sept. 15, 2015 — Suitable for both end users and OEMs, a dual-wavelength excitation light source from Siskiyou Corp. may be used in optongenetics and other life sciences applications.  The IS-LEDc combines the output from two LEDs (read more....)


  • Siskiyou Solves Thermal Issues Associated with Flow Cytometry Miniaturization

    by Michael O'Coyne | Aug 25, 2015

    GRANTS PASS, Or., Aug. 17, 2015 - Although product miniaturization can confer numerous practical advantages, it may create significant design issues - hurdles that need to be overcome to make the miniaturization a reality. Siskiyou Corp., a supplier of positioning equipment for life sciences and which specializes in building hardware for space- and access-restricted applications, has just solved such an obstacle. (read more....)

  • Article for Photonics Spectra - Delivering Superior Mounting Precision

    by Michael O'Coyne | May 20, 2015

    Optical mounts frequently play a critical role in overall laser system performance. Yet their impact often becomes obvious only when system operation degrades due to optical misalignment induced by vibration, thermal drift or long term mechanical creep in mounts. This article reviews basic styles of optical mount design and construction, and compares various mount types in terms of their stability, functionality and cost. (Read More ....)

  • Published Article from BioPhotonics - Comparing Micromanipulators for Electrophysiology

    by Michael O'Coyne | May 20, 2015

    Electrophysiology encompasses the measurement and analysis of transient ion flows and resultant voltage changes across cellular membranes, e.g., sodium ion channels that enable nerve cell signal transmission.  A key, but often unheralded, component of these experiments is the micromanipulation system used by the researcher to maneuver the micropipettes (Read More....)

  • Siskiyou has expanded their Class 1000 cleanroom

    by Michael O'Coyne | May 20, 2015

    3/16/15 – Siskiyou Corporation has expanded their Class 1000 cleanroom manufacturing space to encompass approximately 20% of their Grants Pass, OR, production facility, enabling the company to better meet the needs of OEMs incorporating Siskiyou’s products into high value optical assemblies.  Specifically, the new cleanroom facilities, (Read More ...

  • Siskiyou Patents Improved Method for Optical Mount Adjustment

    by Michael O'Coyne | May 18, 2015

    Siskiyou Corporation has been awarded a US Patent (Patent No. 8,925,409) for a novel actuating mechanism that significantly improves the performance of top adjusted optical mounts and linear translation stages.  Specifically, the Siskiyou invention mechanically isolates the rotation motion of the adjustment screw from the moving part of the mount or stage, so that turning the adjustor imparts only linear, (read more ....)

  • The Siskiyou IS-OGP is a simple, turnkey, modular solution

    by Michael O'Coyne | May 18, 2015

    2/16/15 – The Siskiyou IS-OGP is a simple, turnkey, modular solution (patent pending) for integrating an external laser beam into an existing microscope in optogenetics experiments that utilize a laser spot to stimulate target neurons in the cortex of lab animals.  Specifically, the IS‑OGP provides a means to introduce a fiber-coupled laser beam into the infinity space of leading optical microscopes having a trinocular setup (read more ....)