Siskiyou Corporation has published the following whitepaper articles to guide our customers as they select the right products for their application. Each paper is free for your review, however if you are going to quote from these publications in your documents please be sure to credit authors appropriately. If interested in republishing these items, contact Siskiyou at tech@siskiyou.com and ask for written permission before doing so.
Here you will find featured applications and innovations using our products, Siskiyou is always looking for new ideas to highlight, contact us below if you have an idea for a paper or article:
Whitepapers
Several different technologies offer a choice of performance for patch clamp studies, intracellular recording and other demanding experiments in electrophysiology within the confines of an optical microscope.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
Optical Mounts frequently play a critical role in overall laser system performance. Yet their impact often only becomes obvious when system operation degrades due to optical misalignment induced by vibration, thermal drift of long-term mechanical creep in mounts.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
A simple, modular optomechanical tool breaks barriers by enabling the seamless addition and control of a secondary light source in standard microscopy setups. The cost-efficient tool facilitates not only photoactivation for optogenetics, but also extends microscope imaging capabilities.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
Siskiyou now offers a set of interchangeable modules and accessories for customizing the functionality of optical microscopes from all major manufacturers (Zeiss, Nikon, Olympus), or even building a new microscope.
Imaging transparent, colorless specimens has always presented a challenge in optical microscopy. In many applications, it is not desirable or even possible to use fluorescent dyes, stains or transgenic probes to render target objects more visible. While differential image contrast (DIC), often in the form of the Nomarski microscope, is widely employed, its optical complexity can cause limitations when the contrast image is combined with some other measurement modality or imaging technique (such as patch-clamp measurements or optogenetic stimulation, or even simply epi-fluorescence)...
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
After decades of promise and hype, but very limited market uptake, laser systems for dentistry are finally taking off. One of the leading products is the Solea from Convergent Dental, which provides a superior alternative to the mechanical drill, plus the flexibility of several soft tissue procedures, including wound sealing, and even cutting/ osseous tissue (bone). This article reviews the development of this system, including the use of novel optomechanics from Siskiyou Corporation to simplify system assembly, improve stability and reduce cost.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
From neuroscience to morphogenesis and photosynthesis, optomechanical modules allow researchers to utilize fluorescence microscopy in diverse and increasingly complex studies.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
Optomechanical probe positioners allow more comprehensive study of biological samples. This trending technology is playing a critical, unheralded role in life science research.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
A comprehensive understanding of how the central nervous system communicates with and control muscle function requires unraveling the precise roles of neurotransmitters.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
Reliability and longevity directly impact the cost of using Q-switched, diode pumped, solid state, ultra-violet laser in industrial applications. Damage to the intracavity harmonic crystal is often the major limiting factor in the lifetime of these lasers.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
High-stability flexure mounts were crucial to Opotek's miniaturized, shippable OPO with it's shipping-based technical support model. (a). Thermal stability (averaged over both x and y-axes) is shown for a Siskiyou IXF1.0i monolithic flexure mount and high-stability mounts from two other manufacturers. (b). Thermal performance date for the latter two are from manufacturers' published literature.
Among the DC/servo options, the MX7000 series demonstrated the lowest amount of play and drift compatible with MyoStretcher's target performance (measurement to 1 nN), while providing up to 20 mm of motion in each axis. A motorized actuator with anti-backlash gear-head (in each axis), driving a crossed-roller bearing, highly linear stage, eliminates axial and lateral play, and a pre-loaded screw drive avoids the possibility of drift when stationary - that is, during a typical single myocyte experiment. Also, because the three-axis subsystems were originally developed for demanding electrophysiology (patch clamp) experiments, they are totally compatible with the limited access of a high-magnification optical microscope.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
High optomechanical stability is the key to discriminating nonstandard-shaped cells with trace variance in fluorescence intensity.
by John Wingerd, Siskiyou Corporation, www.siskiyou.com, email:johnw@siskiyou.com
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